THE PHARMACOLOGICAL ACTIVITY OF LEAVES OF ERYTHRINA VARIEGATA LINN., ON METABOLIC SYMPTOMS OF EXPERIMENTALLY INDUCED POLYCYSTIC OVARIAN DISEASE

Abstract

To evaluate the beneficial effect of Ethanolic ext. of Erythrina variegata Linn., in decreasing the major metabolic symptoms assocd. with Letrozole induced Polycystic Ovarian Disease (PCOD or PCOS) using female rat model. Erythrina variegata Linn., is commonly known as Indian coral tree belongs to the family of Fabaceae. Female wistar albino rats were grouped into five groups with six animals each. All rats were daily administered with letrozole (1mg/kg b.tw.) for 21 days except control, and during this period, changes in estrus cycle were obsd. After letrozole treatment, group 2 was considered neg. control, group 3 was considered std., group 4 and 5 were treated orally with Ethanolic ext. of Erythrina variegata Linn., 200 mg/kg b.wt. and 400 mg/kg b.wt., resp., for 4 wk (7 consecutive estrus cycles). Various parameters such as estrus cycle, blood sugar level, lipid profile and wts. of reproductive system were detd. The characteristic of ovary and uterus were evaluated by histopathol. studies. [on SciFinder(R)]