The Effect of Sukun Leaf (Artocarpus altilis) Extract on Collagen Density of Excision Wound Healing in Albino Rats (Rattus norvegicus)

Abstract

The aim of this study was to determine the effect of sukun leaf (Artocarpus altilis) extract on collagen density of excision wound healing in albino rats (Rattus norvegicus). A total of 20 male albino rats were randomly devided into five groups, there were negative control (K-) treated with ointment base, positive control (K+) treated with povidone iodine 10%, treated groups (P1, P2, P3) treated with sukun leaf extract ointment 6,25%; 12,5%; and 25%. Treatment was given every other day for fourteen days. Results of the nonparametric test Kruskal-Wallis showed significant difference (p<0,05) and continued with the Mann-Whitney test. Collagen density groups of P1, P2, and P3 did not different significantly (p>0,05), but significantly different from group K-and K+. The conclusion of this study was sukun leaf extract effective to increase the density of collagen in the healing process of excision wound.