An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-Dihydro-1,2,4-oxadiazoles

Abstract

4,5-Dihydro-1,2,4-oxadiazoles were prepared using 1,3-dipolar cycloaddition of imines with nitrile oxides. Further reductive N-O bond cleavage furnished monosubstituted N-aryl amidines in good yield. Thus an efficient route for the synthesis of monosubstituted N-aryl amidines has been developed.