Niveles de parasitemia y alteraciones histopatológicas en Mus musculus BALB/c infectado con Trypanosoma cruzi obtenido de Panstrongylus chinai del Valle Chamán, La Libertad - Perú

Abstract

Parasitemia levels as well as histopathologycal changes in the heart and the brain of mice, Mus musculus, BALB/c experimentally infected by Trypanosoma cruzi isolated of Panstrongyfus chinai from Chaman Valley (La Libertad-Peru) was determined. For this purposes, ten mice specimens was inoculated with 5x10 4 trypomastigota parasites (0.1 mL of original inoculums) and another one, the witness, was inoculated with saline solution sterile. The parasitemia was evident at fifth day after experimental infection, rising until levels between 2,5x106 and 7,0x10e trypomastigotas/mL before death, that which happened in 100% of experimental mice between 13 to 18 days. On the other hand, the histopathologycal analysis by H/E technique showed edematous areas, vesicular congestion, hipercromasia and amastigota nests in both, heart and encephalon cuts. Moreover, only in encephalon chronic inflammation was detected and only in hearth, lynphocyte-inflamatory infiltred. T. cruzi of P. chinai bug from Chaman Valley showed neurotropic and cardio tropic tendency in M. musculus BALB/c.