Control of amyloid β-peptide protofibril formation by a designed template assembly

Abstract

Insight into amyloids: Four identical segments of the amyloid β-peptide, which is associated with Alzheimer's disease by fibril formation, were successfully attached to a cyclic decapeptide template. The assembly forms soluble protofibrils (see picture) that reveal a cross-β-sheet structure, with fast controllable kinetics and without a lag phase. (Figure Presented) © 2006 Wiley-VCH Verlag GmbH £Co. KGaA.