Effect of cortisone on healing of corneal wounds

Abstract

The effect of cortisone upon the healing of perforating corneal wounds in the rabbit has been studied with small subconjunctival doses of cortisond corresponding to the usual therapeutic level, and with larger non-therapeutic doses. Cortisone was found to inhibit the formation of the fibrinous coagulum, cellular infiltration, fibroblastic repair, and endothelial regeneration. The inhibition was related to the quantity of cortisone administered, being moderate with small doses (with which the final stage of healing was impaired but adequate), and severe with large doses (with which healing may be completely prevented).