Glycemic status and renal function among type 2 diabetics

Abstract

Background:Diabetes mellitus (DM) is characterized by some specific complications including diabetic nephropathy. Urea & creatinine are useful parameters to diagnose the renal function, despite some limitations. Objective:Study aimed to analyze the effect of hyperglycemic condition on the renal function parameter like serum urea and serum creatinine. Methods: It was a cross sectional study. To determine the incidence of kidney dysfunction in type 2 diabetics in Nepalgunj medical college and Hospital, Nepalgunj, Nepal. Random blood samples were taken from 100 diabetic subjects and 100 non-diabetic controls between the period 1st February, 2012 to 31st January, 2013 for investigation of plasma glucose fasting(FPG), blood urea and serum creatinine. These biochemical parameters were determined by using a fully automated clinical chemistry analyzer. The comparison was done by using Student ‘t’ test. Results: Our findings showed that the level of blood urea (P<0.0128 Diabetic male and P=0.0082 Diabetic female) and serum creatinine (P<0.0001 Diabetic male and P0.0187 Diabetic female) were significantly higher in type 2 diabetics as compared to non-diabetics in both male and female. There was no significant difference between diabetic male and female. High serum creatinine level was seen in males than females. Conclusion: In our study there was an increase of blood urea level in type 2 DM. Good control of blood glucose level is absolute requirement to prevent progressive renal impairment.