Abstract Collection from the 10th Annual Meeting of the European Section of the International Academy of Cardiovascular Sciences

Abstract

Immune Mediators and Modulators in Reducing the Size and Inducing Stability of Atherosclerotic Plaques in the Carotid Artery Devendra Agrawal Western University of Health Sciences, Pomona, CA, USA Abstract Prevention of atherosclerotic plaque formation, reduction in plaque burden and stabilization of a vulnerable plaque are of therapeutic significance in decreasing the incidence of acute events. The findings supported the critical role of TLR4 and TREM-1 in underlying pathophysiology of chronic inflammation, atherosclerotic plaque formation and plaque instability. [...]we examined the effect of the selective inhibitors of TREM-1 (LR-12) and TLR4 (TAK242) in a microswine model of carotid artery atherosclerosis. Positive effects of hydrogen gas have previously been reported in cardiac arrest settings in animals and humans. [...]a preventive effect was observed on syndecan-1 release in a rat model of haemorrhagic shock. [...]SZV-2649, similar to amiodarone, has antiarrhythmic effects based on its multiple ion channel blocking properties.