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Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis

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Abstract

Introduction: Neuroinflammation has recently been described in amyotrophic lateral sclerosis (ALS). However, the precise role of such proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in ALS has not yet been determined. In this study, we determined cerebrospinal fluid (CSF) MCP-1 and MIP-1β levels and assessed their association with the duration and severity of ALS. Methods: Concentrations of MCP-1 and MIP-1β were determined in the CSF of 77 patients diagnosed with ALS and 13 controls. Cytokine levels were analysed in relation to ALS duration (< 12 months vs. > 12 months) and severity (< 30 points vs. > 30 points on the ALS Functional Rating Scale administered at hospital admission). Results: Higher CSF MIP-1β (10.68 pg/mL vs. 4.69 pg/mL, P

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Martínez, H. R., Escamilla-Ocañas, C. E., Camara-Lemarroy, C. R., González-Garza, M. T., Moreno-Cuevas, J., & García Sarreón, M. A. (2020). Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis. Neurologia, 35(3), 165–169. https://doi.org/10.1016/j.nrl.2017.07.020

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