Efficacy of amphotericin b at suboptimal dose combined with voriconazole in a murine model of aspergillus fumigatus infection with poor in vivo response to the azole

Abstract

The combination of amphotericin B at a suboptimal dose (0.3 mg/kg) with voriconazole has shown efficacy in prolonging survival and reducing tissue burden in a murine model of disseminated infection by an isolate of Aspergillus fumigatus that had showed a poor in vivo response to the azole. The efficacy of the combined treatment was higher than that obtained with amphotericin B at 0.8 mg/kg. Copyright © 2013, American Society for Microbiology. All Rights Reserved.