Folic acid/methotrexate functionalized mesoporous silica nanoflakes from different supports: Comparative study

6Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, high surface area, and tunable pores. In addition, they can be multifunctionalized. These properties were used to create multifunctional drug delivery systems combining folic acid as a target molecule and methotrexate (MTX) as an anticancer drug. The silica nanoflakes were formed using graphene oxide and double-layered hydroxide as templates, respectively. After the removal of matrices, the silica flakes were functionalized by folic acid and loaded with methotrexate. The differences in drug release performance and structural stability were analyzed with respect to the detailed physicochemical characterization of the produced silica nanoflakes.

Cite

CITATION STYLE

APA

Trukawka, M., Cendrowski, K., Konicki, W., & Mijowska, E. (2020). Folic acid/methotrexate functionalized mesoporous silica nanoflakes from different supports: Comparative study. Applied Sciences (Switzerland), 10(18). https://doi.org/10.3390/APP10186465

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free