Formulation and evaluation of transdermal patches of leaf ethanol extract Lantana Camara Linn with ethyl cellulose-poly vinyl pyrolidone polymer variations

Abstract

Lantana camara Linn is one of the plants that can help the wound healing process because it contains phenolic, flavonoids, and alkaloids that have antibacterial abilities against Staphylococcus epidermidis. but its use is still very simple, therefore it is necessary to develop traditional medicinal preparations in the transdermal patches with a combination of EC (Ethyl Cellulose) and PVP (Poly Vinyl Pyrolidone) polymers. This study aims to see the effect of using ethyl cellulose and polyvinyl pyrrolidone based on the physical characteristics of the Formulation. Lantana camara Linn leaf ethanol extract was obtained by maceration method using 96% ethanol solvent. The transdermal patch formulation was made with 7 formulations with a combination of EC: PVP based on a simple lattice design. Evaluation of the physical properties of the transdermal patch consisted of patch weight test, thickness test, folding endurance test, loss on drying, and moisture uptake. It can be concluded that the results of the evaluation of the preparation showed that F1 was the best preparation with polymer variations EC: PVP: PEG (200 mg: 250 mg: 50 mg) with a patch weight of 1.2213 ± 0.040; patch thickness 6.76 ± 0.251; folding endurance 310.33 ± 6.80; loss on drying 2.37 % ±0.36 and moisture absorption 3.68 % ±0.68.