Étude de la résistance de Plasmodium falciparum aux antipaludiques au sein du réseau international des Instituts Pasteur (RIIP-Palu)

Abstract

Malaria research units within the Institut Pasteur international network (RIIP-Palu) located in Africa, in South- East Asia and in South America, work for many years in close collaboration with the National malaria control programmes. Relying on technical platforms with wellequipped laboratories and scientific expertise, they are at the forefront of research on the antimalarial drug resistance by working together for training young scientists and developping similar protocols allowing comprehensive comparisons. Including fundamental and operational researches, they conduct regional and international projects which aim (1) to detect the emergence of antimalarial drugs resistant parasites and to evaluate their spatio-temporal distribution, (2) to develop in vitro and molecular tools, (3) to identify epidemiological factors involved in the emergence and the spread of antimalarial drugs resistant parasites and (4) to understand the molecular and cellular mechanisms implicated in resistance. In this review, will be presented methodological approaches and data obtained since 2000.