Role of IL-38 and its related cytokines in inflammation

24Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

Cite

CITATION STYLE

APA

Yuan, X., Peng, X., Li, Y., & Li, M. (2015). Role of IL-38 and its related cytokines in inflammation. Mediators of Inflammation, 2015. https://doi.org/10.1155/2015/807976

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free