In vitro biological activity of Salvia leriifolia Benth essential oil relevant to the treatment of Alzheimer's disease

Abstract

In this study the chemical composition, cholinesterase inhibitory property and antiinflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and α-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC50 2.26 μL/mL. Interesting cholinesterase inhibitory activity was also found with IC50 values of 0.32 and 0.29 μL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC50 value of 165 μg/mL. The absence of cytotoxicity at 1000 μg/mL was evaluated by MTT assay in 142BR cells. © 2009 by Japan Oil Chemists' Society.