Association between breast milk adipokines with growth in breast feeding infants, a systematic review and meta-analysis

Abstract

Objectives: Breast milk adipokines are associated with growth, body mass index (BMI) and weight gain in infants. In this study, the effect of breastmilk adipokines (leptin and adiponectin) on the BMI and weight gain of breast-fed infants was evaluated using systematic review and metaanalysis. Materials and methods: We used PRISMA checklist for carrying out this study. 752 articles were collected from the database searching and other sources from 1994 to April 2019. According to the criteria in the study, 25 articles remained for evaluation. Eight papers were related to the effect of breast milk leptin on weight gain and BMI of infants that were evaluated by meta-analyzing. The adiponectin articles were surveyed by systematic review. Results: There was no significant publication bias in the meta-analysis study. The results of random-effect model indicated a reverse and significant correlation between breastmilk leptin with weight gain and BMI (r=-0.331). The adiponectin level in breast milk was associated with the BMI and weight gain of infants. Conclusions: Meta-analysis indicated a significant inverse correlation between breastmilk leptin with weight gain and BMI in infants; furthermore, the systematic review study expressed significant correlation between breast milk adiponectin with growth (BMI and weight gain) in infants.