A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne-

Abstract

In the course of our studies on the further application of licorice as a cosmetic ingredient, we studied a new dermatol. availability in the licorice ext. contg. licochalcone-A as the main component, Polyol Sol. Licorice Ext. P-U, prepd. from the roots of Glycyrrhiza inflata Batalin. As a result, this ext. showed several activities such as inhibitory actions of testosterone 5α-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like actions, which related to skin care, esp. the suppression of acne formation and development. On basis of this evidence, a trial of Polyol Sol. Licorice Ext. P-U with acne patients was carried out and the efficacy was demonstrated clin. [on SciFinder(R)]