Effects of gintonin-enriched fraction in an atopic dermatitis animal model: Involvement of autotaxin regulation

17Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Ginseng extract has been used for prevention of atopic dermatitis (AD) in experimental animal models. However, little is known about its active ingredients and the molecular mechanisms underlying its anti-AD effects. Recently, we isolated a unique lysophosphatidic acid (LPA) receptor ligand, gintonin, from ginseng. Gintonin, the glycolipoprotein fraction of ginseng, contains LPAs, mainly LPA C18 : 2 with other minor lysophospholipid components. A line of evidence showed that serum autotaxin (ATX) activity and level are significantly elevated in human AD patients compared to those in normal controls, which indicates that ATX may be involved in human AD. In a previous study, we demonstrated that gintonin exerted anti-inflammatory effects via inhibition of microglial activation and proinflammatory cytokine production by immune cells and that it strongly inhibited ATX activity. In this study, we investigated whether oral administration of the gintonin-enriched fraction (GEF) could ameliorate the symptoms of 2,4-dinitrofluorobenzene (DNFB)- induced AD in NC/Nga mice. We found that oral administration of GEF to DNFB-induced AD mice for 2 weeks reduced ear swelling and AD skin index. In addition, oral administration of GEF reduced the serum levels of immunoglobulin E, histamine, interleukin-4, and interferon-γ. Histological examination showed that oral administration of GEF attenuated skin inflammation and significantly reduced eosinophil and mast cell infiltration into the skin. Moreover, oral administration of GEF not only decreased serum ATX level but also reduced serum ATX activity. The present study shows that the anti-AD effects of ginseng might be attributed to GEF-induced anti-inflammatory activity and ATX regulation.

References Powered by Scopus

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

305Citations
N/AReaders
Get full text

Regulation of the immune response and inflammation by histamine and histamine receptors

261Citations
N/AReaders
Get full text

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

229Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Panax ginseng as an adjuvant treatment for Alzheimer's disease

127Citations
N/AReaders
Get full text

Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies

57Citations
N/AReaders
Get full text

Panax ginseng: a candidate herbal medicine for autoimmune disease

44Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Lee, B. H., Kim, H. K., Jang, M., Kim, H. J., Choi, S. H., Hwang, S. H., … Nah, S. Y. (2017). Effects of gintonin-enriched fraction in an atopic dermatitis animal model: Involvement of autotaxin regulation. Biological and Pharmaceutical Bulletin, 40(7), 1063–1070. https://doi.org/10.1248/bpb.b17-00124

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

57%

Professor / Associate Prof. 2

29%

Researcher 1

14%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 3

43%

Neuroscience 2

29%

Pharmacology, Toxicology and Pharmaceut... 1

14%

Computer Science 1

14%

Article Metrics

Tooltip
Mentions
References: 1

Save time finding and organizing research with Mendeley

Sign up for free