Comparison of genome-wide expression patterns in response to heavy metal treatment in Saccharomyces cerevisiae 1) cadmium and mercury

Abstract

cDNA microarrays are very convenient tools that can be used to understand changes in genome-wide patterns of gene expression. The yeast DNA microarray contains 5880 ORF cDNA probes, which is almost whole genome, on a glass slide. We analyzed genome-wide transcript profiles following exposure to Cadmium (Cd) or Mercury (Hg) with the yeast DNA microarray, and while 22 genes were induced by both heavy metals, there were many discrepancies in those profiles. From these results, we concluded that yeast microarrays are valuable for bioassay of environmental agents. Copyright 2001 Chem-Bio Informatics Society.