Is there occult tissue ischemia in chronic end-stage liver disease?

Abstract

Whether pathological oxygen supply dependency exists in patients with chronic end-stage liver disease (CESLD) is unknown, although the frequently occurring multiorgan dysfunction seen in these patients may be the result of occult tissue ischemia. In this study, 15 adult patients with CESLD were evaluated for the presence of pathological oxygen supply dependency and, thus, occult tissue ischemia before undergoing orthotopic liver transplantation. Whole-body oxygen consumption (Vo2) was measured using indirect calorimetry at baseline, at reduced oxygen delivery (Do2) using positive end-expiratory pressure, and at increased Do2 using volume infusion. As a group, no significant increase or decrease in Vo2 was observed with changes in Do2. However, 4 patients showed increases in Vo2 of 14%, 10.8%, 9.6%, and 8.2% when Do2 was increased. The study results suggest that pathological oxygen supply dependency is present in a subset of patients with CESLD, and the existence of occult tissue ischemia is speculated.