MP527REMOVAL EVALUATION OF A NEW DIALYZERS WITH MEDIUM CUT-OFF MEMBRANE IN HD TREATMENTS

Abstract

INTRODUCTION AND AIMS: The high-flux dialyzers in standard hemodialysis offer numerous benefits for ESRD patients, such as, increasing the uremic toxins removal in a wide spectrum. New dialyzers with a medium cut-off membrane (MCO, Theranova , Baxter Healthcare), designed to further improve the removal of medium molecules, represent an innovative way to remove uremic toxins. This study was addressed to evaluate the removal efficacy of Theranova in standard HD by the Reduction Rate (RR) in comparison with our data achieved with three different types of online postdilution HDF treatments METHODS: The dialyzers Theranova 400 (sup. 1.7 m2) were assessed in standard HD with blood flow of 300 ml/min by measuring pre and post-HD samples of: Urea, creatinine, beta2-m, myoglobin, hemoglobin, albumin and total serum protein. Data from two routine monthly surveys on each of the 8 stable HD patients (M/F 6/2) were collected. Data are reported as mean +/- standard deviation (SD). RESULT(S): Theranova was well accepted by all the patients and no adverse events were reported. The main results, reported in table 1, showed a high removal rate for all the uremic toxins analyzed. The albumin level was measured before and after the study protocol without changes (3,83+/-0,3 vs and 3,83+/-0,3 g/dl, p=0,999). Comparing our results obtained with the Theranova filter in HD with data in our previous study on infusion management mode in HDF postdilution (see Table 2, *HDF online data derived by Teatini et al Blood Purification 2011;31:259-267), we achieved similar RR(%) for small and light-medium molecules and slightly superior to HDF-OL for medium molecular with higher molecular weight, such as myoglobin (17.800D). CONCLUSION(S): In standard HD, the Theranova 400 dialyzers offer high removal rate for both small andmedium-sizedmolecules (beta2-m, myoglobin), comparable to those achieved in high-volume HDF treatments. It's worth to note that our results with Theranova were obtained with a low surface area than our previous study in HDF online. (Table presented).