Abstract
The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (R free of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.
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Moen, S. O., Fairman, J. W., Barnes, S. R., Sullivan, A., Nakazawa-Hewitt, S., Van Voorhis, W. C., … Edwards, T. E. (2015). Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP. Acta Crystallographica Section F: Structural Biology Communications, 71, 609–614. https://doi.org/10.1107/S2053230X15006883
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