In vitro activity of telavancin against a contemporary worldwide collection of staphylococcus aureus isolates

Abstract

The activity of telavancin and comparators was assessed against a contemporary (2007 and 2008) global collection of 10,000 isolates of Staphylococcus aureus. Telavancin was very active against methicillin- susceptible and -resistant S. aureus (MSSA and MRSA, respectively; MIC 50/90 for both, 0.12/0.25 μg/ml; 100.0% susceptible). This agent was 2-, 4-, and 8-fold more potent than daptomycin (MIC90, 0.5 μg/ml), vancomycin or quinupristin-dalfopristin (MIC90, 1 μg/ml), and linezolid (MIC90, 2 μg/ml) against MRSA, respectively. These data show a potent activity of telavancin tested against a current global collection of S. aureus. Copyright © 2010, American Society for Microbiology. All Rights Reserved.