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Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells

OncoImmunology (2012) 1(5) 762-764
DOI: 10.4161/onci.19681
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Abstract

PGE2 is the key factor needed for MDSCs development, accumulation and functional stability. PGE2 initiates an EP2/EP4- mediated positive feedback between COX2 and PGE2 in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets. ©2012 Landes Bioscience.

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Obermajer, N., & Kalinski, P. (2012). Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells. OncoImmunology, 1(5), 762–764. https://doi.org/10.4161/onci.19681

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