Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc

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Abstract

Fifty-four cyanobacterial strains of the genus Nostoc from different habitats were screened for acetylcholinesterase inhibitory activity. Water-methanolic extracts from freeze-dried biomasses were tested for inhibitory activity using Ellman's spectrophotometric method. Acetylcholinesterase inhibitory activity higher than 90% was found in the crude extracts of Nostoc sp. str. Lukeov 27/97 and Nostoc ellipsosporum Rabenh. str. Lukeov 51/91. Extracts from Nostoc ellipsosporum str. Lukeov 52/91 and Nostoc linckia f. muscorum (Ag.) Elenk. str. Gromov, 1988, CALU-980 inhibited AChE activity by 84.9% and 65.3% respectively. Moderate AChE inhibitory activity (29.137.5%) was found in extracts of Nostoc linckia Roth. str. Gromov, 1962/10, CALU-129, Nostoc muscorum Ag. str. Lukeov 127/97, Nostoc sp. str. Lhotsky, CALU-327 and Nostoc sp. str. Gromov, CALU-998. Extracts from another seven strains showed weak anti-AChE activities. The active component responsible for acetylcholinesterase inhibition was identified in a crude extract of Nostoc sp. str. Lukeov 27/97 using HPLC and found to occur in one single peak.

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APA

Zelík, P., Lukešová, A., Voloshko, L. N., Štys, D., & Kopecký, J. (2009). Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(2), 531–536. https://doi.org/10.1080/14756360802234836

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