Original article: Non-Hodgkin's lymphoma after prolonged remission of Hodgkin's disease in an HTV-infected patient

Abstract

Summary: Hodgkin's disease was diagnosed in a 22-year-old HTV-seropositive man in 1986. Alternate MOPP/ ABVD chemotherapy induced a clinical remission. He was asymptomatic until 3 years later when fever and peripheral and mediastinal lymphadenopathy appeared. Lymph node biopsy showed a large-cell anaplastic lymphoma and EBV genome was identified in the malignant cells, suggesting that transformation might had been induced by EBV. The present case affirms that in patients with HIV-related lymphomas who present enlarging lymphadenopathy after stable remission, the development of lymphomas of higher malignancy needs to be ruled out. © 1991 Kluwer Academic Publishers.