Synthesis of novel macrocyclic Di- and tetralactams containing triazole subunits

Abstract

The new macrocyclic di- and tetralactams 9, 15, and 16 were obtained in 16-24% yields by heating the appropriate bis-amines 7 or 8 with the corresponding bisaldehyde 5 or 14 in refluxing acetic acid under high-dilution conditions.