Nanoscale hydrophilic colloids with high relaxivity and low cytotoxicity based on Gd(III) complexes with Keplerate polyanions

Abstract

The work introduces for the first time Mo-132-type Keplerates (Kp) and Gd3+ ions as a basis for the one-pot synthesis of aqueous colloids with high longitudinal relaxivity (r1 = 96.4 mM-1 s-1 at 20 MHz). The hydrophilic coating of small (3-5 nm) Gdx(Kp)y-based cores provides their colloid stabilization, protection from degradation and low cytotoxicity.