The knoevenagel-doebner reaction on 1,2-O-(2,2,2-Trichloroethylidene) derivatives of D-Gluco- and D-Manno- furanose

Abstract

The synthesis of new α,β-unsaturated furanuronic acid derivatives of α-gluco- (3) β-gluco- (6) and β-manno-chloraloses (9) via a convenient one pot procedure using the Knoevenagel-Doebner reaction approach are described. The dialdofuranose derivatives were reacted with malonic acid under Knoevenagel-Doebner reaction conditions and (E)- α,β-unsaturated furanuronic acid derivatives were obtained. © 2010 licensee MDPI Basel Switzerland.