Palladium-catalyzed three-component Heck/sulfonation/amination leading to quaternary 3,4-dihydroisoquinolinones

Abstract

Quaternary isoquinolinones can be widely found in the numerous drug molecules and natural products. In this work, an efficiently palladium-catalyzed three-component Heck/sulfonation/amination to elaborate a class of quaternary 3,4-dihydroisoquinolinones embedding a newly formed sulfonamide group in the mild reaction conditions has been firstly reported. DABSO was employed as the bench-stable SO2 source. To our delight, this reaction exhibited good tolerance, and various quaternary 3,4-dihydroisoquinolinones could be efficiently elaborated in the mild reaction conditions. Besides, simple aryl iodides could also achieve benzsulfamide derivatives from moderate to excellent yields.