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3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)-H bond functionalization of 2-alkylazaarenes

Organic and Biomolecular Chemistry (2016) 14(24) 5525-5528
DOI: 10.1039/c6ob00108d
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Abstract

A Brønsted acid-catalyzed addition of 2-alkylazaarenes to in situ generated N-sulfonylimines through selective C(sp3)-H bond functionalization has been developed. This protocol provides an atom- and step-economic approach to α-substituted sulfonamides.

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APA

Beisel, T., Kirchner, J., Kaehler, T., Knauer, J., Soltani, Y., & Manolikakes, G. (2016). 3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)-H bond functionalization of 2-alkylazaarenes. Organic and Biomolecular Chemistry, 14(24), 5525–5528. https://doi.org/10.1039/c6ob00108d

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