The use of pethidine and morphine in the presence of monoamine oxidase inhibitors

Abstract

Summary: Fifteen patients being treated with monoamine oxidase inhibitors were given injections of pethidine, morphine and water in a random order. Every patient received a series of four injections of each of these, in increasing doses and at 45-minute intervals. As judged from measurements of their blood pressure and pulse rate, and from observation of the general state of awareness, all patients reacted normally. It is suggested that patients receiving monoamine oxidase inhibitors who require an operation should undergo a sensitivity test to morphine. © 1968 John Sherratt and Son Ltd.