Chaetochromin, a Bis(naphthodihydropyran-4-one) Mycotoxin from Chaetomium thielavioideum: Application of 13C-1H Long-rang Coupling to the Structure Elucidation

Abstract

Details of the separation of the metabolites (I–V) of Chaetomium thielavioideum are presented. The structure of a new mycotoxin named chaetochromin was studied by physical method (ultraviolet, infrared, 1H- and 13C-nuclear magnetic resonance (NMR), and mass spectrum) and it was identified as the bis(naphthodihydropyran-4-one (II). The assignment of the 13C-NMR signals was largely achieved with the aid of the two- and three-bond spin-spin couplings between 13C and 1H. © 1980, The Pharmaceutical Society of Japan. All rights reserved.