Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis

Abstract

Background: BAF (BANF1) is a highly conserved essential protein that binds nuclear lamina proteins and DNA. Results: Perturbing BAF phosphorylation results in nuclear envelope defects and impaired cell cycle progression. Conclusion: Correct regulation of BAF phosphorylation is essential for its cellular function. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.