Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate. © 2014 Le Thomas et al.; licensee BioMed Central Ltd.
CITATION STYLE
Le Thomas, A., Tóth, K. F., & Aravin, A. A. (2014, January 27). To be or not to be a piRNA: Genomic origin and processing of piRNAs. Genome Biology. https://doi.org/10.1186/gb4154
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