Abstract
Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B. © 2009 Japan Antibiotics Research Association All rights reserved.
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Schulz, D., Nachtigall, J., Riedlinger, J., Schneider, K., Poralla, K., Imhoff, J. F., … Süssmuth, R. D. (2009). Piceamycin and its N-acetylcysteine adduct is produced by streptomyces sp. GB 4-2. Journal of Antibiotics, 62(9), 513–518. https://doi.org/10.1038/ja.2009.64
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