Improvement of HPMC tablet disintegration by the addition of inorganic salts

Abstract

Effects of inorganic salts on disintegration of hydroxypropylmethylcellulose (HPMC) matrix tablets have been studied. Adding disintegrants, such as Ac-di-sol® , Primojel® , Kolidon-CL® , or low substituted hydroxypropylcellulose (L-HPC®) to HPMC matrix tablets had no effect on disintegration property. Disintegration time was improved by adding NaHCO3, KH2PO4, K2SO4, KCl, or NaCl to the HPMC tablets as tablet components. On the other hand, addition of Na2CO3, or Na2SO4 to the tablets showed no improvement of disintegration. The heat of dissolution of inorganic salts that improved disintegration of tablets was endothermic, while that of inorganic salts that did not improve disintegration of tablets was exothermic. These results suggested that the thermal environment and ionic strength inside the tablet might affect the disintegration of HPMC matrix tablets. © 2008 Pharmaceutical Society of Japan.