Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl-and arylthiosubstituted maleimides

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Abstract

Bis-Alkylthio maleimido derivatives have been prepared from teicoplanin pseudoaglycon by reaction of its primary amino group with N-ethoxycarbonyl bis-Alkylthiomaleimides. Some of the new derivatives displayed excellent antibacterial activity against resistant bacteria.

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Csávás, M., Miskovics, A., Szcs, Z., Rth, E., Nagy, Z. L., Bereczki, I., … Herczegh, P. (2015). Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl-and arylthiosubstituted maleimides. Journal of Antibiotics, 68(9), 579–585. https://doi.org/10.1038/ja.2015.33

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