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Can CSF spectrophotometry for “Xanthochromia” be used to detect leaking subarachnoid aneurysms in patients with sickle cell anemia with negative MRI or CT angiogram despite hyperbilirubinemia?

Clinical Case Reports (2020) 8(5) 894-899
DOI: 10.1002/ccr3.2775
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Abstract

CSF (Cerebrospinal Fluid) xanthochromia by spectroscopy should not be dismissed in the context of hyperbilirubinemia in a patient with sickle cell anemia. Xanthochromia detected by spectrophotometry offers a vital clue that further invasive diagnosis is required.

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Siu, W. Y., Thomas, W., Trivedi, R., Hogan, A., Siddiqi, U., Sarker, A., & Besser, M. W. (2020). Can CSF spectrophotometry for “Xanthochromia” be used to detect leaking subarachnoid aneurysms in patients with sickle cell anemia with negative MRI or CT angiogram despite hyperbilirubinemia? Clinical Case Reports, 8(5), 894–899. https://doi.org/10.1002/ccr3.2775

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