Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice

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Abstract

The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of γ-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.

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Matsuo, H., Ryu, M., Nagata, A., Uchida, T., Kawakami, J. I., Yamamoto, K., … Sawada, Y. (1998). Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice. Antimicrobial Agents and Chemotherapy, 42(3), 691–694. https://doi.org/10.1128/aac.42.3.691

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