Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway

11Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Numerous studies have aimed to develop novel advanced vaccines, in part because traditional vaccines have been unsuccessful in preventing rapidly emerging and reemerging viral and bacterial infections. There is a need for an advanced vaccine delivery system to ensure the successful induction of humoral and cellular immune responses. In particular, the ability of nanovaccines to modulate intracellular antigen delivery by inducing exogenous antigens (loaded onto major histocompatibility complex class 1 molecules) in CD8+ T cells, the so-called cross-presentation pathway, has attracted a great deal of attention. Protection against viral and intracellular bacterial infections relies on cross-presentation. This review discusses the advantages, requirements, and preparation of nanovaccines, the cross-presentation mechanism, the several parameters affecting cross-presentation by nanovaccines, and future perspectives.

Cite

CITATION STYLE

APA

Kim, C. G., Lee, J. C., Ju, D. B., Kim, S. K., Yun, C. H., & Cho, C. S. (2023, June 1). Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway. Tissue Engineering and Regenerative Medicine. Korean Tissue Engineering and Regenerative Medicine Society. https://doi.org/10.1007/s13770-023-00527-y

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free