Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults

Abstract

Aim: To investigate the association between ACTN3 R577X polymorphism and appendicular skeletal muscle mass, walking speed, and muscle strength in older adults. Findings: RR homozygosity in the ACTN3 gene was associated with a lower likelihood of having low muscle mass. However, no significant association existed between ACTN3 polymorphism and walking speed or muscle strength. Message: ACTN3 R577X polymorphism may be associated with muscle mass but not physical function in terms of walking speed and muscle strength in older adults.