Plasma markers of myocardial inflammation at isolated atrial fibrillation

Abstract

Background: Atrial fibrillation (AF) is one of the widest spread forms of arrhythmia, which is associated with the increased mortality and thromboembolic complications. To date, the involvement of renin-angiotensin-aldosterone system and immunomedi-ators of inflammation into the mechanisms of development and maintenance of isolated AF is not clear. Specificity of their changes with respect to the latent myocarditis at AF is not proved. Methods: In 96 patients with persistent isolated atrial fibrillation (IsAF), scheduled for radiofrequency ablation and endomyocardial biopsy (EMB), and in 20 healthy volunteers (HVT), levels of plasma tumor necrosis factor-a (TNF-a), interleukin (IL)-1b, IL-6, IL-8, IL-10, fatty acid-binding protein (FABP), neopterin, C-reactive protein (CRP) were determined by ELISA, level of aldosterone and the renin activity were determined by radioimmunoassay. Results were compared between the study and HVT groups and related to the EMB data. Results: Endomyocardial biopsy revealed lymphocytic myocarditis in 29%, immuno-histochemical signs of viruses’ persistence in the myocardium—in 43.8% of patient. We formed 4 subgroups: «myocarditis», «fibrosis», «virus positive», «virus negative». In the group «myocarditis», level of IL-6 was significantly higher than in group «fibro-sis» (P 1.6 pg/mL, P 13.2 nmol/L, P