Functional Role of microRNAs in Regulating Cardiomyocyte Death

Abstract

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.