A pH tuning single fluorescent probe based on naphthalene for dual-analytes (Mg2+and Al3+) and its application in cell imaging

Abstract

In this study, a naphthalene Schiff-basePwhich serves as a dual-analyte probe for the quantitative detection of Al3+and Mg2+has been designed. The proposed probe showed an ‘‘off-on’’ fluorescent response toward Al3+in ethanol-water solution (1 : 9, v/v, pH 6.3, 20 mM HEPES) over other metal ions and anions, while the detection by the probe could be switched to Mg2+by regulating the pH from 6.3 to 9.4. The sensing mechanisms ofPto Al3+/Mg2+are attributed to inhibition of the photo-induced electron transfer (PET) process by the formation of 1 : 1 ligand-metal complexes. More importantly, the probe was applied successfully in living cells for the fluorescent cell-imaging of Al3+and Mg2+