Convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP).

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Abstract

We herein report a convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP) through the modified H-phosphonate chemistry. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as protecting group for the 2'-hydroxy functions of ribonucleosides. Homogeneous cdiGMP was obtained after removal of the protecting groups.

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APA

Yan, H., & Humes, E. (2006). Convenient synthesis of 3’,5’-cyclic diguanylic acid (cdiGMP). Nucleic Acids Symposium Series (2004), (50), 5–6. https://doi.org/10.1093/nass/nrl003

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