Combined analysis of CSF Tau, A 42, A 142 and A 1 40 ox in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia

Abstract

We studied the diagnostic value of CSF A42/tau versus low A142 and high A1 40 ox levels for differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), respectively. CSF of 45 patients with AD, 15 with DLB, 21 with Parkinson's disease dementia (PDD), and 40 nondemented disease controls (NDC) was analyzed by A-SDS-PAGE/immunoblot and ELISAs (A42 and tau). A42/tau lacked specificity in discriminating AD from DLB and PDD. Best discriminating biomarkers were A142 and A1 40 ox for AD and DLB, respectively. AD and DLB could be differentiated by both A142 and A1 40 ox with an accuracy of 80 at minimum. Thus, we consider A142 and A1 40 ox to be useful biomarkers for AD and DLB, respectively. We propose further studies on the integration of A142 and A1 40 ox into conventional assay formats. Moreover, future studies should investigate the combination of A1 40 ox and CSF alpha-synuclein for the diagnosis of DLB. © 2010 Mirko Bibl et al.