New finger-occlusion plethysmograph for estimating peripheral blood flow and vascular resistance

Abstract

Background: The aim of the present study was to measure peripheral blood flow (BF) with a new finger-occlusion plethysmograph (FOP) and to compare this to BF measured with a laser Doppler flowmeter (LDF). An additional objective was to investigate the relationship between hypertension-related clinical parameters and peripheral vascular resistance (PVR) estimated from BF and mean blood pressure (BP) (PVR =mean BP/BF) in young subjects. Methods and Results: The present study employed 101 young volunteers (61 males, 40 females, mean age 23.2±2,5 years). The FOP was attached to the third finger and an LDF to the fourth fingertip of each subject. BF was measured simultaneously by the 2 devices. A multi-biomedical recorder (TM2425) measured 24-h BP. A high correlation was observed between BF measured by the FOP and LDF (r=0.79, p<0.001). In multiple linear regression analysis, PVR was independently correlated with a family history of hypertension (p<0.01) and with base diastolic BP during sleep (p<0.01), which is a sensitive predictor of severity of hypertension. Conclusions: Our newly developed FOP can estimate peripheral absolute BF easily. Furthermore, BF determined by the FOP can be used to calculate PVR, and an elevated PVR may be a useful predictor of hypertension.