Case Report of Vedolizumab Treatment of Refractory Ulcerative Colitis Associated with Psoriasis

Abstract

The patient had a long history of difficult to control psoriasis and ulcerative colitis and was dependent on corticosteroids. Multiple treatment schemes including several attempts with tumor necrosis factor (anti-TNF) antagonists had had acceptable clinical responses but subsequently lost effectiveness. During acute exacerbation of colitis, vedolizumab was used and achieved remarkable clinical improvement. During maintenance, deep healing was achieved (endoscopic and histological normalization). In addition, there was significant improvement of psoriasis lesions during follow-up. This is the first case to be published of the use of Vedolizumab to treat this condition in Colombia.