Clinical and Epidemiological Factors Predicting the Severity of Psoriasis

Abstract

Introduction: Psoriasis, a systemic disease with a chronic course, is associated with a high degree of comorbidities and decreased quality of life. Aims: The aims of the study were to analyze epidemiological data of a large cohort of patients diagnosed with psoriasis over 8 years and to assess factors related to psoriasis severity and impact on quality of life. Research methods: A transversal study was performed on 1236 persons diagnosed with psoriasis in an OutPatient Dermatology Center between January 1, 2004 and December 31, 2011. Clinical examination was done and medical records were complied including: type of psoriasis, number of body locations at the onset and at the moment of examination, severity index, family history of psoriasis, comorbidities, past and current treatments, demographic characteristics, residence, level of education, working status and income, smoking, and alcohol intake. Linear regression was used for multivariable analysis. Key results of the chapter: Comorbidities were present in 36.1% of patients with mild form of psoriasis, 44.05% with moderate forms, and in 19.64% of severe psoriasis. Onset and clinical examination age, education level, residence, job, gender, and smoking were significant factors associated with severity of psoriasis.